Atorvastatin calcium Basic information
Product Name: |
Atorvastatin calcium |
Synonyms: |
Atorvastatin Calcium Anhydrous;Calcium of atorvastatin;Atorvastatin ;Atorvastatin aMorphous;atorvastatine calciuM salt;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid CalciuM Salt;Atorvastatin HeMicalciuM;Sortis |
CAS: |
134523-03-8 |
MF: |
C66H68CaF2N4O10 |
MW: |
1155.36 |
EINECS: |
200-659-6 |
Atorvastatin calcium Chemical Properties
Melting point |
176-178°C |
storage temp. |
Store at +4°C |
solubility |
DMSO: ≥10mg/mL |
form |
white powder |
Atorvastatin calcium Usage And Synthesis
Mode of action |
Atorvastatin takes effect through selectively and competitively inhibiting the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway. This results in a subsequent decrease in hepatic cholesterol levels. Decreased hepatic cholesterol levels stimulates upregulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations. |
Chemical Properties |
White Crystalline Powder |
Uses |
The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. |
Atorvastatin calcium Specification
Character |
A white or almost white?crystalline powder |
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Identification |
A: IR. |
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water |
3.5~5.5 |
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Ca % |
3.0~3.6 |
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Particle size |
D90≤10 µm |
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Heavy Metals(ppm) |
≤20 |
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Impurity |
Impurity E |
≤0.3% |
|
Impurity A |
≤0.3% |
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Impurity?B |
≤0.3% |
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Impurity C |
≤0.3% |
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Impurity D |
≤0.1% |
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Other individual unknown Impurity % |
≤0.1% |
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Total impurity |
≤1.0% |
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Assay % |
98.0-102.0 |
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